Steris Healthcare Private Limited

Oxcarbazepine 450 mg Tablet is an effective antiepileptic (anti-seizure) medication designed to help control and prevent seizures in patients with epilepsy. It works by stabilizing the electrical activity in the brain, reducing abnormal nerve impulses that cause convulsions.

This medicine is commonly prescribed as part of long-term epilepsy management, either alone or in combination with other anti-seizure drugs. With consistent use under medical supervision, Oxcarbazepine 450 mg helps individuals achieve better seizure control and improve quality of life.

Composition

Each tablet contains:
Oxcarbazepine – 450 mg

Uses of Oxcarbazepine 450 mg Tablet

• Epilepsy (Partial Seizures):
  Oxcarbazepine is primarily used to treat partial seizures, which may or may not spread to other parts of the brain.

• Generalized Seizures:
  It helps prevent generalized tonic-clonic seizures by reducing the excessive neuronal firing in the brain.

• Adjunct Therapy:
  Can be used in combination with other anti-epileptic medications for patients who do not respond adequately to single-drug therapy.

• Mood Stabilization (Off-label use):
  In some cases, doctors may prescribe Oxcarbazepine to stabilize mood in patients with bipolar disorder, though this is an off-label use.

How Oxcarbazepine 450 mg Works

Oxcarbazepine acts by blocking voltage-sensitive sodium channels in the brain, which prevents the rapid and repetitive firing of neurons that trigger seizures. This action helps restore normal nerve activity and prevents abnormal brain signals responsible for convulsions.

Key Benefits

✅ Effective Seizure Control:
Helps reduce the frequency and intensity of seizures, promoting better neurological stability.

✅ Well-Tolerated Therapy:
Compared to older antiepileptic drugs, Oxcarbazepine is associated with fewer side effects and drug interactions.

✅ Dual Usage:
Can be used as both a monotherapy (alone) or adjunct therapy (with other antiepileptics).

✅ Improved Quality of Life:
By preventing unpredictable seizures, patients experience improved confidence, sleep quality, and daily functioning.

✅ Pediatric and Adult Use:
Suitable for both adults and children (as prescribed by a healthcare professional).While Oxcarbazepine 450 mg is generally safe and effective, some patients may experience mild to moderate side effects.

Common and possible adverse effects include:

• Dizziness or Drowsiness

• Nausea and Vomiting

• Headache

• Fatigue or Weakness

• Double Vision or Blurred Vision

• Loss of Coordination or Balance

• Skin Rash or Itching

• Low Sodium Levels (Hyponatremia) — may cause confusion, headaches, or seizures in rare cases.

Serious Side Effects (Rare):
Seek medical attention immediately if you experience:

• Severe allergic reactions (swelling of lips, throat, or face)

• Persistent vomiting or confusion

• Signs of depression or mood changes

MAYORANDIL 5 is a clinically trusted cardiac care medication containing Nicorandil 5 mg as its active pharmaceutical ingredient. Nicorandil is a potassium channel opener with nitrate-like properties, used primarily in the management and prevention of angina pectoris (chest pain) associated with coronary artery disease. By improving blood flow to the heart and reducing cardiac workload, MAYORANDIL 5 helps prevent anginal attacks and enhances overall cardiac function.

Manufactured under strict quality control and Good Manufacturing Practices (GMP), MAYORANDIL 5 ensures purity, stability, and consistent therapeutic efficacy. It is prescribed widely by cardiologists for long-term angina management and cardiac protection in patients with ischemic heart conditions.

 

Composition

• Active Ingredient: Nicorandil 5 mg

• Dosage Form: Film-coated tablet

• Therapeutic Category: Antianginal agent / Vasodilator

 

How MAYORANDIL 5 Works

Nicorandil, the key component in MAYORANDIL 5, acts through a dual mechanism that uniquely combines the properties of nitrates and potassium channel openers:

1. Nitrate-like Action:
   Nicorandil donates nitric oxide (NO) in the vascular smooth muscle, which activates guanylate cyclase, leading to an increase in cyclic GMP levels. This causes vasodilation of veins and arteries, reducing both preload and afterload on the heart. As a result, oxygen demand of the myocardium is decreased, alleviating angina symptoms.

2. Potassium Channel Opening Action:
   By opening ATP-sensitive potassium channels in vascular smooth muscles, Nicorandil enhances coronary blood flow and protects the heart muscle from ischemic injury. This action improves myocardial oxygenation and prevents coronary artery spasms.

This dual mechanism makes MAYORANDIL 5 a unique antianginal therapy that offers cardioprotection beyond symptomatic relief.

 

Uses of MAYORANDIL 5

MAYORANDIL 5 (Nicorandil 5 mg) is used in the treatment and prevention of:

• Chronic Stable Angina: To relieve chest pain and prevent its recurrence.

• Coronary Artery Disease (CAD): Improves blood supply to the heart muscles by dilating coronary arteries.

• Post-Angioplasty or Post-Bypass Therapy: Enhances myocardial perfusion and prevents ischemic episodes.

• Ischemic Heart Disease (IHD): Provides symptomatic relief and reduces the frequency of angina attacks.

• Adjunct Therapy: In combination with other cardiac medications like beta-blockers, calcium channel blockers, or nitrates, for comprehensive heart care. 

 

Key Benefits of MAYORANDIL 5

1. Improves Oxygen Supply to the Heart:
   Nicorandil increases coronary blood flow and decreases the oxygen demand of cardiac muscles, preventing ischemic pain.

2. Dual Mechanism for Better Protection:
   Combines nitrate-like vasodilation with potassium channel opening for enhanced antianginal action.

3. Reduces Frequency and Severity of Angina:
   Regular use minimizes angina attacks, improving patient comfort and physical endurance.

4. Prevents Coronary Artery Spasm:
   Helps maintain smooth coronary circulation, especially beneficial for patients with variant or vasospastic angina.

5. Cardioprotective Role:
   Offers protection to the myocardium during ischemia and reduces oxidative stress on the heart.

6. Better Tolerability:
   Unlike long-acting nitrates, Nicorandil does not commonly cause tolerance or rebound angina, ensuring consistent efficacy.