Steris Healthcare Private Limited

HYCHLORZIDE 12.5 is a trusted and effective diuretic medication that contains Hydrochlorothiazide (12.5mg) as its active ingredient. Hydrochlorothiazide is widely used to manage hypertension (high blood pressure) and edema (fluid retention) associated with various medical conditions. By promoting the excretion of excess salt and water from the body, HYCHLORZIDE 12.5 helps in maintaining optimal blood pressure levels and reducing the risk of serious cardiovascular events.

 

Key Benefits: 

• Blood Pressure Management: HYCHLORZIDE 12.5 is highly effective in controlling high blood pressure, which helps in preventing complications such as heart attacks, strokes, and kidney problems.
• Edema Relief: The diuretic action of Hydrochlorothiazide helps in reducing swelling and fluid retention caused by conditions like congestive heart failure, liver cirrhosis, and renal dysfunction.
• Heart Health: By maintaining healthy blood pressure levels, HYCHLORZIDE 12.5 supports overall cardiovascular health and reduces the strain on the heart.
• Kidney Function Support: The medication aids in the proper functioning of the kidneys by preventing excess fluid buildup and promoting effective filtration.

 

How It Works: 

HYCHLORZIDE 12.5 works by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubules of the kidneys. This leads to increased excretion of sodium, chloride, and water in the urine, thereby reducing blood volume and blood pressure. The reduction in fluid accumulation also alleviates edema and associated symptoms. By maintaining optimal fluid balance and blood pressure, HYCHLORZIDE 12.5 helps in preventing potential complications and improve overall health.

 

Directions for Use: 

• Take HYCHLORZIDE 12.5 exactly as prescribed by your healthcare provider.
• The usual recommended dose is one tablet per day, preferably in the morning.
• Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
• Follow your doctor's instructions regarding diet, fluid intake, and other medications.
• Regular monitoring of blood pressure and kidney function is essential while using this medication.

 

Side Effects: 

Like all medications, HYCHLORZIDE 12.5 may cause some side effects. Common side effects include:

• Dizziness or lightheadedness, especially when standing up quickly
• Increased urination
• Electrolyte imbalance (e.g., low potassium or sodium levels)
• Fatigue or weakness
• Headache
• Nausea or vomiting

 

Hypertension, commonly known as high blood pressure, is one of the leading causes of cardiovascular disease in India. Sedentary lifestyles, high salt intake, stress, obesity, and genetic factors have significantly increased the number of people requiring long-term blood pressure management. Uncontrolled hypertension can lead to serious complications such as heart attack, stroke, kidney failure, and vision problems.

OLMISTRUM TRIO 20 is a comprehensive triple-drug antihypertensive formulation containing Olmesartan Medoxomil 20 mg, Cilnidipine 10 mg, and Chlorthalidone 12.5 mg. This powerful combination is designed to provide effective, sustained, and well-balanced blood pressure control in patients whose hypertension is not adequately controlled with single or dual therapy.

Composition of OLMISTRUM TRIO 20

Each film-coated tablet contains:

• Olmesartan Medoxomil – 20 mg

• Cilnidipine – 10 mg

• Chlorthalidone – 12.5 mg

Excipients: q.s.

This triple combination targets different mechanisms responsible for high blood pressure, ensuring optimal therapeutic outcomes.

Understanding Hypertension and the Need for Combination Therapy

Hypertension is often a multifactorial condition, meaning it occurs due to multiple physiological mechanisms. In many patients, a single antihypertensive agent may not be sufficient to achieve target blood pressure levels.

Combination therapy:

• Improves blood pressure control

• Reduces cardiovascular risk

• Minimises dose-related side effects

• Enhances patient compliance

OLMISTRUM TRIO 20 is especially beneficial for patients with moderate to severe hypertension or those at high cardiovascular risk.

How Does OLMISTRUM TRIO 20 Work?1. Olmesartan Medoxomil

Olmesartan is an angiotensin II receptor blocker (ARB). It relaxes blood vessels by blocking the action of angiotensin II, a hormone responsible for blood vessel constriction. This leads to:

• Reduced vascular resistance

• Lower blood pressure

• Protection of the heart and kidneys

2. Cilnidipine

Cilnidipine is a dual L-type and N-type calcium channel blocker. It:

• Relaxes arterial blood vessels

• Reduces sympathetic nerve activity

• Minimises reflex tachycardia

• Offers additional renal and cardiovascular protection

3. Chlorthalidone

Chlorthalidone is a thiazide-like diuretic that helps:

• Eliminate excess salt and water from the body

• Reduce blood volume

• Enhance the antihypertensive effect of other drugs

Together, these agents provide 24-hour blood pressure control with improved tolerability.